Irinotecan hydrochloride trihydrate is a drug of choice in the treatment of colon cancer. The purpose of this study was to investigate the anticancer activity of anticancer drug irinotecan hydrochloride trihydrate in maltodextrin based proniosomes towards human Colon cancer cell lines (SW-620). MTT (3-(4, 5-Dimethyl thiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay was used for quantitative measurements for the anticancer cell activity. Proniosomes of Irinotecan hydrochloride trihydrate were prepared by slurry method using different surfactants. The formulations were then characterized with respect to vesicle size. The size of the vesicles was in the range of 3.18±1.65 to 4.16±2.68 µm respectively. The findings of this study inferred that formulation PN5 showed better cytotoxicity effect with IC 50 value of 38 µg.
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